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ZADITEN (ZADITOR)® 1 mg/5 ml Oral Solution
Ketotifen (as Ketotifen hydrogen fumarate)
Read all of this leaflet carefully because it contains important information for you.
-Keep this leaflet. You may need to read it again.
-Ask your pharmacist if you need more information or advice.
-You must contact a doctor if your symptoms worsen or do not improve.
-If any of the side effects gets serious, or if you notice any side effect not listed in this leaflet, please tell your doctor or pharmacist.
In this leaflet:
1.What ZADITEN (ZADITOR) is and what it is used for
2.Before you take ZADITEN (ZADITOR)
3.How to take ZADITEN (ZADITOR)
4.Possible side effects
5.How to store ZADITEN (ZADITOR)
1. WHAT ZADITEN (ZADITOR) IS AND WHAT IT IS USED FOR
The name of your medicine is ZADITEN (ZADITOR) and it contains ketotifen. It belongs to a group of drugs which have anti-allergic activities and it is used to help prevent asthma attacks and treat allergic conditions such as rhinitis.
2. BEFORE YOU TAKE ZADITEN (ZADITOR)
Do not take ZADITEN (ZADITOR)
-if you are allergic (hypersensitive) to ketotifen or any of the other ingredients (see section 6) of ZADITEN (ZADITOR).
Take special care with ZADITEN (ZADITOR)
-Do not stop taking other asthma medications unless your doctor tells you to, however well you feel.
-During the first few days of treatment your reactions may be impaired (i.e. you may feel drowsy or your reactions may be slower than usual, even if you do not feel drowsy). You should not take charge of vehicles or machinery until the effect of your medicine on your reactions is known.
-ZADITEN (ZADITOR) may increase the effects of sedatives, anti-histamines, medicines used to treat depression or anxiety and alcohol.
-As ZADITEN (ZADITOR) may lower the seizure threshold it should be used with caution in patients with a history of epilepsy.
Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
-If you are taking any medicines for diabetes
-If you are taking any other medicines for asthma
-If you are taking any sedatives, medicines to treat depression or anxiety, or anti-histamines (medicines used to treat cold and flu)
Taking ZADITEN (ZADITOR) with food and drink
-You should not drink alcohol whilst taking ZADITEN (ZADITOR).
Pregnancy and breast-feeding
-Ask your doctor or pharmacist for advice before taking any medicine.
-It is not recommended to take ZADITEN (ZADITOR) during pregnancy. If you become pregnant whilst taking ZADITEN (ZADITOR), tell your doctor.
-Ketotifen is excreted in breast milk; therefore mothers receiving ZADITEN (ZADITOR) should not breast‐feed.
Driving and using machines
During the first days of treatment with ZADITEN (ZADITOR) reactions may be impaired. Do not to take charge of vehicles or machinery until the effect of ZADITEN (ZADITOR) treatment on the individual is known.
Important information about some of the ingredients of ZADITEN (ZADITOR)
Contains maltitol liquid (hydrogenated glucose syrup). If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.
This medicine contains parahydroxybenzoates as a preservative and may cause allergic reactions (possibly delayed).
This medicinal product contains 2 vol % ethanol (alcohol), i.e. up to 100 mg per dose, equivalent to 2 ml beer and 0.83 ml wine per dose. Harmful for those suffering from alcoholism. To be taken into account in pregnant or breast-feeding women, children and high-risk groups such as patients with liver disease, or epilepsy.
3. HOW TO TAKE ZADITEN (ZADITOR)
Always take ZADITEN (ZADITOR) exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure.
-Your doctor will tell you how much oral solution to take and when to take it. It is important that you follow your doctor’s instructions exactly and never change the dose yourself, however well you feel.
-Ask your doctor or pharmacist if you are unsure about how much solution to take or when to take it.
-You should take ZADITEN (ZADITOR) with food.
-Do not stop taking ZADITEN (ZADITOR) unless your doctor tells you to, however well you feel. Discontinuation of treatment should take place gradually over a 2 to 4 week period.
The usual dose is:
Adults and the Elderly:
1 mg (1 x 5 ml spoonful) twice daily. If necessary the dose may be increased to 2 mg (2 x 5 ml spoonful) twice daily. Patients known to be easily sedated should begin treatment with 0.5 to 1 mg (2.5 ml to 5 ml spoonful) at night for the first few days.
2 to 3 years:
Dosage: 0.05 mg (=0.25 ml ZADITEN (ZADITOR) Oral Solution) per kilogram body weight twice daily (morning and evening).
3 years and above:
1 mg (1 x 5 ml spoonful) twice daily with food.
Use in the elderly:
No evidence exists that elderly patients require different dosages or show different side effects from younger patients.
If you take more ZADITEN (ZADITOR) than you should
If you accidentally take too much ZADITEN (ZADITOR), tell your doctor immediately or go to your nearest casualty department.
If you forget to take ZADITEN (ZADITOR)
If you miss one dose take it as soon as you remember and take your next dose at its regularly scheduled time. If you miss more than one dose do not take a double dose to make up for forgotten one, just continue with your normal schedule.
If you stop taking ZADITEN (ZADITOR)
Do not stop taking ZADITEN (ZADITOR) unless your doctor tells you to, however well you feel. Discontinuation of treatment should take place gradually over a 2 to 4 week period.
4. POSSIBLE SIDE EFFECTS
Like all medicines, ZADITEN (ZADITOR) can cause side effects, although not everybody gets them. Some very rare effects could be serious:
Likely to affect fewer than 1 of every 10,000 patients
-If you have skin rash, redness of the skin, blistering of the lips, eyes and mouth accompanied with fever, chills, headache, cough and body aches
-If you have a yellowing of the skin and eyes, coloured bowel motions, dark coloured urine (signs of jaundice, liver disorder, hepatitis)
If any of these apply to you, tell your doctor straight away.
Common side effects:
Likely to affect between 1 and 10 of every 100 patients
-Inability to sleep (insomnia)
Uncommon side effects:
Likely to affect fewer than 1 of every 100 patients
-Burning sensation when passing urine and need to urinate frequently and urgently (cystitis)
Rare side effects:
Likely to affect less than 1 of every 1,000 patients
If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.
5. HOW TO STORE ZADITEN (ZADITOR)
Keep out of the reach and sight of children.
Do not use ZADITEN (ZADITOR) after the expiry date which is stated on the carton and label after EXP. The expiry date refers to the last day of the month.
Do not store above 25°C.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.
6. FURTHER INFORMATION
What ZADITEN (ZADITOR) contains
-The active substance is ketotifen (as the hydrogen fumarate), Each 5 ml of oral solution contains 1 mg ketotifen.
-The other ingredients are propyl parahydroxybenzoate (E216), methyl parahydroxybenzoate (E218), strawberry flavour liquid, citric acid anyhydrous (E330), disodium hydrogen phosphate (E450), ethanol, liquid maltitol (hydrogenated glucose syrup) and purified water.
What ZADITEN (ZADITOR) looks like and contents of the pack
The oral solution is a clear, colourless medicine with a strawberry odour. Brown glass bottles with a polyethylene closure containing 300 ml.
Amber glass bottle with a child resistant, tamper evident closure containing 300 ml. Not all pack sizes may be marketed.
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